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1. 发明申请

WO2017020043A3 BIOSYNTHESIS OF POLYKETIDES 审中-公开
标题翻译： POLYKETIDES的生物合成
公开(公告)号：WO2017020043A3
公开(公告)日：2017-07-13
申请号：PCT/US2016045037
申请日：2016-08-01
申请人： UNIV RICE WILLIAM M
发明人： GONZALEZ RAMON , CHEONG SEOKJUNG , CLOMBURG JAMES M
IPC分类号： C12N1/21 , C12N9/10 , C12N15/82
CPC分类号： C12P7/26 , C12N9/1029
摘要： This disclosure generally relates to the use of microorganisms to make various functionalized polyketides through polyketoacyl-CoA thiolase-catalyzed non-decarboxylative condensation reactions instead of decarboxylative reactions catalyzed by polyketide synthases. Native or engineered polyketoacyl-CoA thiolases catalyze the non-decarboxylative Claisen condensation in an iterative manner (i.e. multiple rounds) between two either unsubstituted or functionalized ketoacyl-CoAs (and polyketoacyl-CoAs) serving as the primers and acyl- CoAs serving as the extender unit to generate (and elongate) polyketoacyl-CoAs. Before the next round of polyketoacyl-CoA thiolase reaction, the β-keto group of the polyketide chain of polyketoacyl-CoA can be reduced and modified step-wise by 3-OH-polyketoacyl-CoA dehydrogenase or polyketoenoyl-CoA hydratase or polyketoenoyl-CoA reductase. Dehydrogenase converts the β-keto group to β-hydroxy group. Hydratase converts the β- hydroxy group to α-β-double-bond. Reductase converts the α-β-double-bond to single bond. Spontaneous or thioesterase catalyzed termination reaction terminates the elongation of polyketide chain of polyketoacyl-CoA at any point through CoA removal and spontaneous reactions rearrange the structure, generating the final functional polyketide products.
摘要翻译：本公开一般涉及微生物通过聚酮酰辅酶A硫解酶催化的非脱羧缩合反应而不是由聚酮化合物合酶催化的脱羧反应来制备各种官能化聚酮化合物的用途。天然或工程改造的聚酮酰基-CoA硫解酶以反复方式（即多轮）在作为引物的未取代的或官能化的酮酰基-CoA（和聚酮酰基-CoA）和充当扩展剂的酰基-CoA之间催化非脱羧Claisen缩合单元以产生（并拉长）聚酮酰辅酶A。在下一轮聚酮酰辅酶A硫解酶反应之前，聚酮酰辅酶A的聚酮化合物链的β-酮基可被还原并通过3-OH-聚酮酰辅酶A脱氢酶或多酮酰辅酶A水合酶或多酮酰辅酶A 还原酶。脱氢酶将β-酮基转化为β-羟基。水合酶将β-羟基转化为α-β-双键。还原酶将α-β-双键转化为单键。自发或硫酯酶催化的终止反应通过CoA去除终止聚酮酰辅酶A的聚酮化合物链的延长，并且自发反应重新排列结构，产生最终的功能性聚酮化合物产物。

2. 发明申请

WO2016133571A3 LASER INDUCED GRAPHENE HYBRID MATERIALS FOR ELECTRONIC DEVICES 审中-公开
标题翻译：用于电子设备的激光诱导石墨混合材料
公开(公告)号：WO2016133571A3
公开(公告)日：2016-10-13
申请号：PCT/US2015062832
申请日：2015-11-27
申请人： UNIV RICE WILLIAM M
发明人： TOUR JAMES M , LI LEI , PENG ZHIWEI , ZHANG JIBO
IPC分类号： B32B9/00 , B32B3/00
CPC分类号： H01G11/36 , C01B32/184 , C01B32/194 , C01B32/20 , C01B2204/04 , C01B2204/22 , C01B2204/32 , H01M4/587 , H01M4/625 , Y02E60/13
摘要： In some embodiments, the present disclosure pertains to methods of producing a graphene hybrid material by exposing a graphene precursor material to a laser source to form a laser-induced graphene, where the laser-induced graphene is derived from the graphene precursor material. The methods of the present disclosure also include a step of associating a pseudocapacitive material (e.g., a conducting polymer or a metal oxide) with the laser-induced graphene to form the graphene hybrid material. The formed graphene hybrid material can become embedded with or separated from the graphene precursor material. The graphene hybrid materials can also be utilized as components of an electronic device, such as electrodes in a microsupercapacitor. Additional embodiments of the present disclosure pertain to the aforementioned graphene hybrid materials and electronic devices.
摘要翻译：在一些实施方案中，本公开内容涉及通过将石墨烯前体材料暴露于激光源以形成激光诱导的石墨烯来生产石墨烯混合材料的方法，其中所述激光诱导的石墨烯衍生自所述石墨烯前体材料。本公开的方法还包括将假电容材料（例如，导电聚合物或金属氧化物）与激光诱导的石墨烯缔合以形成石墨烯混合材料的步骤。形成的石墨烯混合材料可以与石墨烯前体材料嵌入或分离。石墨烯混合材料也可以用作电子器件的组件，例如微型电容器中的电极。本公开的另外的实施方案涉及上述石墨烯混合材料和电子装置。

3. 发明申请

WO2015175060A3 LASER INDUCED GRAPHENE MATERIALS AND THEIR USE IN ELECTRONIC DEVICES 审中-公开
标题翻译：激光诱导的石墨材料及其在电子设备中的应用
公开(公告)号：WO2015175060A3
公开(公告)日：2016-02-25
申请号：PCT/US2015016165
申请日：2015-02-17
申请人： UNIV RICE WILLIAM M
发明人： TOUR JAMES M , LIN JIAN , PENG ZHIWEI , KITTRELL CARTER
IPC分类号： C01B31/04
CPC分类号： H01M4/587 , C01B32/184 , C01B2204/04 , C01P2006/40 , C08G73/10 , H01G11/06 , H01G11/36 , H01G11/68 , H01G11/70 , H01M4/366 , H01M4/625 , H01M4/663 , H01M10/0525 , H01M10/054 , Y02E60/13
摘要： In some embodiments, the present disclosure pertains to methods of producing a graphene material by exposing a polymer to a laser source. In some embodiments, the exposing results in formation of a graphene from the polymer. In some embodiments, the methods of the present disclosure also include a step of separating the formed graphene from the polymer to form an isolated graphene. In some embodiments, the methods of the present disclosure also include a step of incorporating the graphene material or the isolated graphene into an electronic device, such as an energy storage device. In some embodiments, the graphene is utilized as at least one of an electrode, current collector or additive in the electronic device. Additional embodiments of the present disclosure pertain to the graphene materials, isolated graphenes, and electronic devices that are formed by the methods of the present disclosure.
摘要翻译：在一些实施方案中，本公开涉及通过将聚合物暴露于激光源来生产石墨烯材料的方法。在一些实施方案中，曝光导致从聚合物形成石墨烯。在一些实施方案中，本公开的方法还包括将形成的石墨烯与聚合物分离以形成分离的石墨烯的步骤。在一些实施例中，本公开的方法还包括将石墨烯材料或分离的石墨烯结合到诸如能量存储装置的电子装置中的步骤。在一些实施例中，石墨烯被用作电子设备中的电极，集电器或添加剂中的至少一个。本公开的另外的实施方案涉及通过本公开的方法形成的石墨烯材料，分离的石墨烯和电子器件。

4. 发明申请

WO2015171743A3 ARTIFICIAL, FLEXIBLE VALVES AND METHODS OF FABRICATING AND SERIALLY EXPANDING THE SAME 审中-公开
标题翻译：人工，柔性阀及其制造方法及其扩展方法
公开(公告)号：WO2015171743A3
公开(公告)日：2015-12-17
申请号：PCT/US2015029442
申请日：2015-05-06
申请人： BAYLOR COLLEGE MEDICINE , UNIV RICE WILLIAM M
发明人： JUSTINO HENRI , HARRINGTON DANIEL , CHUN KWONSOO
IPC分类号： A61F2/24 , A61F2/82 , A61F2/86
CPC分类号： A61F2/2418 , A61F2/2415 , A61F2220/0008 , A61F2230/0008 , A61F2230/0069 , A61F2250/0098
摘要： One aspect of the invention provides an artificial, flexible valve including: a stent defining a wall and a plurality of leaflets extending from the wall of the stent. The plurality of leaflets form a plurality of coaptation regions between two adjacent leaflets. The coaptation regions include extensions along a z-axis and adapted and are configured to form a releasable, but substantially complete seal when the leaflets are in a closed position. Another aspect of the invention provides an artificial, flexible valve including: a stent defining a wall and a plurality of leaflets extending from the wall of the stent. Each of the plurality of leaflets terminates in a commissure line. The commissure lines deviate from a hyperbola formed in the x-y plane by at least one deviation selected from the group consisting of: a deviation in the z-direction and one or more curves relative to the hyperbola.
摘要翻译：本发明的一个方面提供了一种人造的柔性阀，包括：支架，其限定壁和从支架的壁延伸的多个小叶。多个传单在两个相邻传单之间形成多个接合区域。接合区域包括沿z轴的延伸部分，并且适于并且构造成当传单处于关闭位置时形成可释放但基本上完整的密封。本发明的另一方面提供一种人造的柔性阀，包括：支架，其限定壁和从支架的壁延伸的多个传单。多个传单中的每一个终止于连合线。连合线偏离在x-y平面上形成的双曲线，所述双曲线选自由以下组成的组中的至少一个偏差：z方向上的偏差和相对于双曲线的一个或多个曲线。

5. 发明申请

WO2015163841A9 MULTIFUNCTIONAL CHEMO- AND MECHANICAL THERAPEUTICS 审中-公开
标题翻译：多功能化学和机械疗法
公开(公告)号：WO2015163841A9
公开(公告)日：2015-12-17
申请号：PCT/US2014034784
申请日：2014-04-21
申请人： UNIV RICE WILLIAM M
发明人： LAPOTKO DMITRI , HLEB KATSIARYNA , KUPFERMAN MICHAEL E , WAGNER DANIEL SCUDDER , TORCHILIN VLADIMIR , WU XIANGWEI
IPC分类号： A61K47/48
CPC分类号： A61K41/0028 , A61K9/107 , A61K31/337 , A61K31/513 , A61K31/704 , A61K33/24 , A61K47/6851 , A61K47/6923 , A61K47/6929
摘要： Methods of treating diseases through the intracellular enhancement and synergy of chemo- and radiation- therapies by employing cancer cell-specific on-demand mechanical intracellular impact. The methods, quadrapeutics, combines four clinically validated modalities: encapsulated drugs, colloidal gold nanoparticles (GNPs), near-infrared short laser pulses, and X-rays.
摘要翻译：通过使用癌细胞特异性按需机械细胞内影响，通过细胞内增强和化学疗法和放射疗法的协同作用来治疗疾病的方法。方法四联疗法结合了四种临床验证的模式：包封药物，胶体金纳米颗粒（GNP），近红外短激光脉冲和X射线。

6. 发明申请

WO2014089214A3 CARBON NANOPARTICLE ADDITIVES FOR WELLBORE FLUID CONDUCTIVITY 审中-公开
标题翻译：碳纳米管添加剂用于井筒流体电导率
公开(公告)号：WO2014089214A3
公开(公告)日：2014-09-04
申请号：PCT/US2013073123
申请日：2013-12-04
申请人： UNIV RICE WILLIAM M , MI LLC
发明人： TOUR JAMES M , CERIOTTI GABRIEL , SLESAREV ALEXANDER , YE RUQUAN , PRICE-HOELSCHER KATHERINE , BOVET CARA , FRIEDHEIM JIM , YOUNG STEVE
IPC分类号： B82Y30/00 , C09K8/34 , E21B7/15
CPC分类号： C09K8/32 , C09K8/03 , C09K2208/10 , E21B47/12 , G01V3/18 , G01V3/24 , Y02A90/342
摘要： Various embodiments of the present disclosure provide methods of making wellbore fluids with enhanced electrical conductivities. In some embodiments, such methods comprise: (1) pre-treating a carbon material with an acid; and (2) adding the carbon material to the wellbore fluid. Further embodiments of the present disclosure pertain to wellbore fluids formed by the methods of the present disclosure. Additional embodiments of the present disclosure pertain to methods for logging a subterranean well by utilizing the aforementioned wellbore fluids.
摘要翻译：本公开的各种实施方案提供了制造具有增强的电导率的井筒流体的方法。在一些实施方案中，这些方法包括：（1）用酸预处理碳材料; 和（2）将碳材料加入到井筒流体中。本公开的另外的实施例涉及通过本公开的方法形成的井眼流体。本公开的另外的实施例涉及通过利用上述井眼流体测井地下井的方法。

7. 发明申请

WO2012048068A3 GRAPHENE-BASED MATERIAL FOR SHALE STABILIZATION AND METHOD OF USE 审中-公开
标题翻译：用于压片稳定性的基于石墨的材料及其使用方法
公开(公告)号：WO2012048068A3
公开(公告)日：2012-08-02
申请号：PCT/US2011055028
申请日：2011-10-06
申请人： MI LLC , UNIV RICE WILLIAM M , YOUNG STEVE , FRIEDHEIM JAMES , PATEL ARVIND D , TOUR JAMES , KOSYNKIN DMITRY
发明人： YOUNG STEVE , FRIEDHEIM JAMES , PATEL ARVIND D , TOUR JAMES , KOSYNKIN DMITRY
IPC分类号： C09K8/04 , C09K8/035 , C09K8/60 , C09K8/68
CPC分类号： C09K8/035 , C09K8/032 , C09K2208/12 , E21B7/00
摘要： Methods and compositions for use in drilling a wellbore into an earthen formation that includes the use of a graphene-based material, where the graphene-based material may be at least one of graphene, graphene oxide, chemically converted graphene, and derivatized graphite oxide are shown and described. In certain examples, the methods and compositions reduce permeability damage and/or stabilize shales.
摘要翻译：用于将井眼钻入包括使用石墨烯材料的土层中的方法和组合物，其中所述石墨烯基材料可以是石墨烯，氧化石墨烯，化学转化的石墨烯和衍生化的氧化石墨中的至少一种，显示和描述。在某些实例中，方法和组合物减少了渗透性损失和/或稳定了页岩。

8. 发明申请

WO2011127148A1 PRODUCTION OF HIGHLY CONDUCTIVE CARBON NANOTUBE-POLYMER COMPOSITES 审中-公开
标题翻译：高导电性碳纳米管 - 聚合物复合材料的生产
公开(公告)号：WO2011127148A1
公开(公告)日：2011-10-13
申请号：PCT/US2011031393
申请日：2011-04-06
申请人： UNIV RICE WILLIAM M , BARRERA ENRIQUE , CHAKRAVARTHI DIVYA KANNAN , SALMAN AHMAD , SEARFASS MICHAEL , KISSELL KYLE
发明人： BARRERA ENRIQUE , CHAKRAVARTHI DIVYA KANNAN , SALMAN AHMAD , SEARFASS MICHAEL , KISSELL KYLE
IPC分类号： H01B1/00
CPC分类号： H01B1/24 , B82Y30/00 , H01B13/0036 , Y10S977/75 , Y10S977/752 , Y10T428/24132 , Y10T428/249921
摘要： In various embodiments, the present invention provides method of forming composites. Such methods generally comprise: (1) applying carbon nanotubes onto a system, wherein the system comprises at least one of an electric field or a magnetic field, and wherein the at least one electric field or magnetic field unidirectionally aligns the carbon nanotubes; and (2) applying a polymer onto the carbon nanotubes while the carbon nanotubes are unidirectionally aligned by the at least one electric field or magnetic field. The application of the polymer onto the carbon nanotubes forms composites that comprise unidirectionally aligned carbon nanotubes embedded in the polymer. In further embodiments, the present invention provides polymer composites formed by the methods of the present invention. Such polymer composites generally comprise: (1) a polymer, wherein the polymer forms a polymer matrix; and (2) a plurality of carbon nanotubes, wherein the carbon nanotubes are unidirectionally aligned and embedded in the polymer matrix.
摘要翻译：在各种实施例中，本发明提供了形成复合材料的方法。这样的方法通常包括：（1）将碳纳米管施加到系统上，其中所述系统包括电场或磁场中的至少一个，并且其中所述至少一个电场或磁场单向地排列所述碳纳米管; 和（2）在碳纳米管通过至少一个电场或磁场单向排列的同时将聚合物施加到碳纳米管上。聚合物在碳纳米管上的应用形成包含嵌入聚合物中的单向排列的碳纳米管的复合材料。在进一步的实施方式中，本发明提供了通过本发明的方法形成的聚合物复合材料。这种聚合物复合材料通常包含：（1）聚合物，其中聚合物形成聚合物基质; 和（2）多个碳纳米管，其中碳纳米管单向排列并嵌入聚合物基质中。

9. 发明申请

WO2009058443A3 POLYOL FUNCTIONALIZED WATER SOLIBLE CARBON NANOSTRUCTURES 审中-公开
标题翻译：多功能水溶性碳纳米管结构
公开(公告)号：WO2009058443A3
公开(公告)日：2010-05-06
申请号：PCT/US2008070914
申请日：2008-07-23
申请人： UNIV RICE WILLIAM M , KHABASHESKU VALERY N , KUZNETSOV OLEKSANDR , LOBO RUI
发明人： KHABASHESKU VALERY N , KUZNETSOV OLEKSANDR , LOBO RUI
IPC分类号： C01B31/02
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/152 , C01B32/174 , C01B32/18 , C01B32/28 , C01B2202/02 , C01B2202/04 , C01B2202/06
摘要： A method of making a water soluble carbon nanostructure includes treating a fluorinated carbon nanostructure material with a polyol in the presence of a base. A water soluble carbon nanostructure comprises a fluorinated carbon nanostructure covalently bound to a polyol. Exemplary uses of water soluble carbon nanostructures include use in polymer composites, biosensors and drug delivery vehicles.
摘要翻译：制备水溶性碳纳米结构的方法包括在碱的存在下用多元醇处理氟化碳纳米结构材料。水溶性碳纳米结构包括与多元醇共价结合的氟化碳纳米结构。水溶性碳纳米结构的示例性用途包括用于聚合物复合材料，生物传感器和药物递送载体。

10. 发明申请

WO2008054839A3 CARBON NANOTUBE DIAMETER SELECTION BY PRETREATMENT OF METAL CATALYSTS ON SURFACES 审中-公开
标题翻译：通过预处理金属催化剂在表面上的碳纳米管直径选择
公开(公告)号：WO2008054839A3
公开(公告)日：2009-04-30
申请号：PCT/US2007063298
申请日：2007-03-05
申请人： UNIV RICE WILLIAM M , HAUGE ROBERT H , XU YA-QIONG , SHAN HONGWEI , NICHOLAS NOLAN WALKER , KIM MYUNG JONG , SCHMIDT HOWARD K , KITTRELL W CARTER
发明人： HAUGE ROBERT H , XU YA-QIONG , SHAN HONGWEI , NICHOLAS NOLAN WALKER , KIM MYUNG JONG , SCHMIDT HOWARD K , KITTRELL W CARTER
IPC分类号： C01B31/02
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/162 , C01B2202/02 , C01B2202/08 , C01B2202/36
摘要： A new and useful nanotube growth substrate conditioning processes is herein disclosed that allows the growth of vertical arrays of carbon nanotubes where the average diameter of the nanotubes can be selected and/or controlled as compared to the prior art.
摘要翻译：本文公开了一种新的有用的纳米管生长衬底调理方法，其允许碳纳米管的垂直阵列的生长，其中与现有技术相比，可以选择和/或控制纳米管的平均直径。

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